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ALPHA-SYNUCLEIN OVEREXPRESSION IN MICE ALTERS SYNAPTIC COMMUNICATION IN THE CORTICOSTRIATAL PATHWAY

α-Synuclein (α-Syn) is a presynaptic protein implicated in Parkinson’s disease (PD). Mice overexpressing human wildtype (WT) α-Syn under the Thy1 promoter show high levels of α-Syn in cortical and subcortical regions, exhibit progressive sensorimotor anomalies, as well as non-motor abnormalities and...

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Bibliografiske detaljer
Main Authors: Wu, Nanping, Joshi, Prasad R., Cepeda, Carlos, Masliah, Eliezer, Levine, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707301/
https://ncbi.nlm.nih.gov/pubmed/20029978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22327
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