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Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human α-Synuclein

Overexpression or mutation of α-synuclein (α-Syn), a protein associated with presynaptic vesicles, causes familial forms of Parkinson’s disease in humans and is also associated with sporadic forms of the disease. We used in vivo microdialysis, tissue content analysis, behavioral assessment, and whol...

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הוצא לאור ב:	J Neurosci Res
Main Authors:	Lam, Hoa A., Wu, Nanping, Cely, Ingrid, Kelly, Rachel L., Hean, Sindalana, Richter, Franziska, Magen, Iddo, Cepeda, Carlos, Ackerson, Larry C., Walwyn, Wendy, Masliah, Eliezer, Chesselet, Marie-Françoise, Levine, Michael S., Maidment, Nigel T.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2011
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4755488/ https://ncbi.nlm.nih.gov/pubmed/21488084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jnr.22611
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Elevated Tonic Extracellular Dopamine Concentration and Altered Dopamine Modulation of Synaptic Activity Precede Dopamine Loss in the Striatum of Mice Overexpressing Human α-Synuclein

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