Functional genomic screening reveals splicing of the EWS-FLI1 fusion transcript as a vulnerability in Ewing sarcoma

Ewing sarcoma cells depend on the EWS-FLI1 fusion transcription factor for cell survival. Using an assay of EWS-FLI1 activity and genome-wide RNAi screening, we have identified proteins required for the processing of the EWS-FLI1 pre-mRNA. We show Ewing sarcoma cells harboring a genomic breakpoint t...

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Published in:Cell Rep
Main Authors: Grohar, Patrick J., Kim, Suntae, Rangel Rivera, Guillermo O., Sen, Nirmalya, Haddock, Sara, Harlow, Matt L., Maloney, Nichole K., Zhu, Jack, O’Neill, Maura, Jones, Tamara L., Huppi, Konrad, Grandin, Magdalena, Gehlhaus, Kristen, Klumpp-Thomas, Carleen A., Buehler, Eugen, Helman, Lee J., Martin, Scott E., Caplen, Natasha J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755295/
https://ncbi.nlm.nih.gov/pubmed/26776507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.063
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