Identification of small molecule inhibitors of hyperpolarization-activated cyclic nucleotide gated channels

Hyperpolarization-activated cyclic nucleotide gated (HCN) channels function in the brain to limit neuronal excitability. Limiting the activity of these channels has been proposed as a therapy for Major Depressive Disorder, but the critical role of HCN channels in cardiac pacemaking has limited effor...

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Pubblicato in:J Biomol Screen
Autori principali: Han, Ye, Lyman, Kyle, Clutter, Matt, Schiltz, Gary E., Ismail, Quratul-Ain, Prados, Diego Bleifuss, Luan, Chi-Hao, Chetkovich, Dane M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755285/
https://ncbi.nlm.nih.gov/pubmed/26045196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057115589590
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