Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

BACKGROUND: The interaction of the envelope glycoprotein of HIV-1 (gp120/gp41) with coreceptor molecules has important implications for specific cellular targeting and pathogenesis. Experimental and theoretical evidences have shown a role for gp41 in coreceptor tropism, although there is no consensu...

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Publicat a:Virol J
Autors principals: Pacheco-Martínez, Elena, Figueroa-Medina, Evangelina, Villarreal, Carlos, Cocho, Germinal, Medina-Franco, José L., Méndez-Lucio, Oscar, Huerta, Leonor
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754869/
https://ncbi.nlm.nih.gov/pubmed/26879054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-016-0486-6
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