Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

BACKGROUND: Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiretroviral compounds that bind in an allosteric binding pocket in HIV-1 RT, located about 10 Å from the polymerase active site. Binding of an NNRTI causes structural changes that perturb the alignment of the prime...

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Bibliografiske detaljer
Udgivet i:Retrovirology
Main Authors: Smith, Steven J., Pauly, Gary T., Akram, Aamir, Melody, Kevin, Rai, Ganesha, Maloney, David J., Ambrose, Zandrea, Thomas, Craig J., Schneider, Joel T., Hughes, Stephen H.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754833/
https://ncbi.nlm.nih.gov/pubmed/26880034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0244-2
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