Chronic Activation of Innate Immunity Correlates With Poor Prognosis in Cancer Patients Treated With Oncolytic Adenovirus

Despite many clinical trials conducted with oncolytic viruses, the exact tumor-level mechanisms affecting therapeutic efficacy have not been established. Currently there are no biomarkers available that would predict the clinical outcome to any oncolytic virus. To assess the baseline immunological p...

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Udgivet i:Mol Ther
Main Authors: Taipale, Kristian, Liikanen, Ilkka, Juhila, Juuso, Turkki, Riku, Tähtinen, Siri, Kankainen, Matti, Vassilev, Lotta, Ristimäki, Ari, Koski, Anniina, Kanerva, Anna, Diaconu, Iulia, Cerullo, Vincenzo, Vähä-Koskela, Markus, Oksanen, Minna, Linder, Nina, Joensuu, Timo, Lundin, Johan, Hemminki, Akseli
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754537/
https://ncbi.nlm.nih.gov/pubmed/26310629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.143
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