Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer

A major hindrance in gene therapy trials with adeno-associated virus (AAV) vectors is the presence of neutralizing antibodies (NAbs) that inhibit AAV transduction. In this study, we used directed evolution techniques in vitro and in mouse muscle to select novel NAb escape AAV chimeric capsid mutants...

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Detaylı Bibliyografya
Yayımlandı:Mol Ther
Asıl Yazarlar: Li, Chengwen, Wu, Shuqing, Albright, Blake, Hirsch, Matthew, Li, Wuping, Tseng, Yu-Shan, Agbandje-McKenna, Mavis, McPhee, Scott, Asokan, Aravind, Samulski, R Jude
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754536/
https://ncbi.nlm.nih.gov/pubmed/26220272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.134
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