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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7

Tumour suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid phosphatase that negatively regulates growth factor-induced survival signalling. Here, we demonstrate that PTEN attenuates epidermal growth factor receptor (EGFR) signalling by promoting late endosome matur...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Shinde, Swapnil Rohidas, Maddika, Subbareddy
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754336/
https://ncbi.nlm.nih.gov/pubmed/26869029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10689
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