Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells

In our continued focus on 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) analogs, we synthesized a novel series of 3,9-substituted α-carboline derivatives and evaluated the new compounds for antiproliferactive effects. Structure activity relationships revealed that a COOCH(3) or CH(2)OH group a...

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Publicado no:Eur J Med Chem
Main Authors: Lin, Yi-Chien, Chen, Yi-Fong, Tseng, Li-Shin, Lee, Yueh-Hsuan, Morris-Natschke, Susan L, Kuo, Sheng-Chu, Yang, Ning-Sun, Lee, Kuo-Hsiung, Huang, Li-Jiau
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754133/
https://ncbi.nlm.nih.gov/pubmed/26820553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.01.004
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