Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase

Novel 6,7-methylenedioxy-4-substituted phenylquinolin-2-one derivatives 12a–n were designed and prepared through an intramolecular cyclization reaction and evaluated for in vitro anticancer activity. Among the synthesized compounds, 6,7-methylenedioxy-4-(2,4-dimethoxyphenyl)quinolin-2(1H)-one (12e)...

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Bibliographic Details
Main Authors: Chen, Yi-Fong, Lin, Yi-Chien, Huang, Po-Kai, Chan, Hsu-Chin, Kuo, Sheng-Chu, Lee, Kuo-Hsiung, Huang, Li-Jiau
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822768/
https://ncbi.nlm.nih.gov/pubmed/23867385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.06.046
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