Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

BACKGROUND AND PURPOSE: 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. EXPERIMENTAL APPROACH: Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivat...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Chen, Yi-Fong, Lin, Yi-Chien, Morris-Natschke, Susan L, Wei, Chen-Fang, Shen, Ting-Chen, Lin, Hui-Yi, Hsu, Mei-Hua, Chou, Li-Chen, Zhao, Yu, Kuo, Sheng-Chu, Lee, Kuo-Hsiung, Huang, Li-Jiau
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337696/
https://ncbi.nlm.nih.gov/pubmed/25363404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12992
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