Extreme dNTP Pool Changes and Hypermutability in dcd ndk Strains

Cells lacking deoxycytidine deaminase (DCD) have been shown to have imbalances in the normal dNTP pools that lead to multiple phenotypes, including increased mutagenesis, increased sensitivity to oxidizing agents, and to a number of antibiotics. In particular, there is an increased dCTP pool, often...

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Gepubliceerd in:Mutat Res
Hoofdauteurs: Tse, Lawrence, Kang, Tina Manzhu, Yuan, Jessica, Mihora, Danielle, Becket, Elinne, Maslowska, Katarzyna H., Schaaper, Roel M., Miller, Jeffrey H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753124/
https://ncbi.nlm.nih.gov/pubmed/26789486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.12.004
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