Extreme dNTP Pool Changes and Hypermutability in dcd ndk Strains

Cells lacking deoxycytidine deaminase (DCD) have been shown to have imbalances in the normal dNTP pools that lead to multiple phenotypes, including increased mutagenesis, increased sensitivity to oxidizing agents, and to a number of antibiotics. In particular, there is an increased dCTP pool, often...

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Udgivet i:Mutat Res
Main Authors: Tse, Lawrence, Kang, Tina Manzhu, Yuan, Jessica, Mihora, Danielle, Becket, Elinne, Maslowska, Katarzyna H., Schaaper, Roel M., Miller, Jeffrey H.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753124/
https://ncbi.nlm.nih.gov/pubmed/26789486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2015.12.004
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