Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

BACKGROUND: Modulation of cardiac repolarization by sexual hormones is controversial and hormonal effects on ion channels remain largely unknown. In the present translational study, we therefore assessed the relationship between QTc duration and gonadal hormones and studied underlying mechanisms. ME...

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Dettagli Bibliografici
Pubblicato in:Eur Heart J
Autori principali: Anneken, Lars, Baumann, Stefan, Vigneault, Patrick, Biliczki, Peter, Friedrich, Corinna, Xiao, Ling, Girmatsion, Zenawit, Takac, Ina, Brandes, Ralf P., Kissler, Stefan, Wiegratz, Inka, Zumhagen, Sven, Stallmeyer, Birgit, Hohnloser, Stefan H., Klingenheben, Thomas, Schulze-Bahr, Eric, Nattel, Stanley, Ehrlich, Joachim R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
Soggetti:
Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753025/
https://ncbi.nlm.nih.gov/pubmed/26271031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv371
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