Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

BACKGROUND: Modulation of cardiac repolarization by sexual hormones is controversial and hormonal effects on ion channels remain largely unknown. In the present translational study, we therefore assessed the relationship between QTc duration and gonadal hormones and studied underlying mechanisms. ME...

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Enregistré dans:
Détails bibliographiques
Publié dans:Eur Heart J
Auteurs principaux: Anneken, Lars, Baumann, Stefan, Vigneault, Patrick, Biliczki, Peter, Friedrich, Corinna, Xiao, Ling, Girmatsion, Zenawit, Takac, Ina, Brandes, Ralf P., Kissler, Stefan, Wiegratz, Inka, Zumhagen, Sven, Stallmeyer, Birgit, Hohnloser, Stefan H., Klingenheben, Thomas, Schulze-Bahr, Eric, Nattel, Stanley, Ehrlich, Joachim R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Basic Science
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753025/
https://ncbi.nlm.nih.gov/pubmed/26271031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv371
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