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Estradiol regulates human QT-interval: acceleration of cardiac repolarization by enhanced KCNH2 membrane trafficking

BACKGROUND: Modulation of cardiac repolarization by sexual hormones is controversial and hormonal effects on ion channels remain largely unknown. In the present translational study, we therefore assessed the relationship between QTc duration and gonadal hormones and studied underlying mechanisms. ME...

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Detalhes bibliográficos
Publicado no:Eur Heart J
Main Authors: Anneken, Lars, Baumann, Stefan, Vigneault, Patrick, Biliczki, Peter, Friedrich, Corinna, Xiao, Ling, Girmatsion, Zenawit, Takac, Ina, Brandes, Ralf P., Kissler, Stefan, Wiegratz, Inka, Zumhagen, Sven, Stallmeyer, Birgit, Hohnloser, Stefan H., Klingenheben, Thomas, Schulze-Bahr, Eric, Nattel, Stanley, Ehrlich, Joachim R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753025/
https://ncbi.nlm.nih.gov/pubmed/26271031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehv371
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