N-Terminal Arginines Modulate Plasma-Membrane Localization of Kv7.1/KCNE1 Channel Complexes

BACKGROUND AND OBJECTIVE: The slow delayed rectifier current (I(Ks)) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits. While most evidence suggests a role of KCNE1 transmembrane domain and C-terminus for the interactio...

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Bibliographic Details
Main Authors: Girmatsion, Zenawit, Biliczki, Peter, Takac, Ina, Schwerthelm, Christin, Hohnloser, Stefan H., Ehrlich, Joachim R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208574/
https://ncbi.nlm.nih.gov/pubmed/22073228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026967
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