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Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block

Based on the consistent demonstration of fibrosis of the atrioventricular node surrounded by macrophages and multinucleated giant cells in anti-Ro antibody exposed fetuses dying with heart block, this study focuses on macrophage signaling stimulated by ssRNA associated with the Ro60 protein and the...

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Dades bibliogràfiques
Publicat a:J Autoimmun
Autors principals: Clancy, Robert M., Markham, Androo J., Reed, Joanne H., Blumenberg, Miroslav, Halushka, Marc K., Buyon, Jill P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752853/
https://ncbi.nlm.nih.gov/pubmed/26432597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.09.003
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