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Ro60-Associated Single-Stranded RNA Links Inflammation with Fetal Cardiac Fibrosis via Ligation of TLRs: A Novel Pathway to Autoimmune-Associated Heart Block

Activation of TLR by ssRNA after FcγR-mediated phagocytosis of immune complexes (IC) may be relevant in autoimmune-associated congenital heart block (CHB) where the obligate factor is a maternal anti-SSA/Ro Ab and the fetal factors, protein/RNA on an apoptotic cardiocyte and infiltrating macrophages...

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Detalhes bibliográficos
Main Authors: Clancy, Robert M., Alvarez, David, Komissarova, Elena, Barrat, Franck J., Swartz, Jordan, Buyon, Jill P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551297/
https://ncbi.nlm.nih.gov/pubmed/20089705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902248
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