Renal Cell Carcinomas in Vinylidene Chloride Exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation

Vinylidene Chloride (VDC) has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 mice to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increases in renal cell hyperplasia, adenoma, and carcinoma (RCCs). Among...

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Pubblicato in:Toxicol Pathol
Autori principali: Hayes, Schantel A., Pandiri, Arun R., Ton, Thai-vu T., Hong, Hue-Hua L., Clayton, Natasha P., Shockley, Keith R., Peddada, Shyamal D., Gerrish, Kevin, Wyde, Michael, Sills, Robert C., Hoenerhoff, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752433/
https://ncbi.nlm.nih.gov/pubmed/26682919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623315610820
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