Renal Cell Carcinomas in Vinylidene Chloride Exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation

Vinylidene Chloride (VDC) has been widely used in the production of plastics and flame retardants. Exposure of B6C3F1 mice to VDC in the 2-year National Toxicology Program carcinogenicity bioassay resulted in a dose-dependent increases in renal cell hyperplasia, adenoma, and carcinoma (RCCs). Among...

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Publié dans:Toxicol Pathol
Auteurs principaux: Hayes, Schantel A., Pandiri, Arun R., Ton, Thai-vu T., Hong, Hue-Hua L., Clayton, Natasha P., Shockley, Keith R., Peddada, Shyamal D., Gerrish, Kevin, Wyde, Michael, Sills, Robert C., Hoenerhoff, Mark J.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752433/
https://ncbi.nlm.nih.gov/pubmed/26682919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0192623315610820
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