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Long-read single-molecule real-time (SMRT) full gene sequencing of cytochrome P450-2D6 (CYP2D6)

The CYP2D6 enzyme metabolizes ~25% of common medications, yet homologous pseudogenes and copy-number variants (CNVs) make interrogating the polymorphic CYP2D6 gene with short-read sequencing challenging. Therefore, we developed a novel long-read, full gene CYP2D6 single-molecule real-time (SMRT) seq...

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Publicat a:Hum Mutat
Autors principals: Qiao, Wanqiong, Yang, Yao, Sebra, Robert, Mendiratta, Geetu, Gaedigk, Andrea, Desnick, Robert J., Scott, Stuart A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752389/
https://ncbi.nlm.nih.gov/pubmed/26602992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/humu.22936
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