Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.

1. In microsomes prepared from three human livers, methadone competitively inhibited the O-demethylation of dextromethorphan, a marker substrate for CYP2D6. The apparent Ki value of methadone ranged from 2.5 to 5 microM. 2. Two hundred and fifty-two (252) white Caucasians, including 210 unrelated he...

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Detalhes bibliográficos
Main Authors: Wu, D, Otton, S V, Sproule, B A, Busto, U, Inaba, T, Kalow, W, Sellers, E M
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1381486/
https://ncbi.nlm.nih.gov/pubmed/8448065
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