Development of a Topical Treatment for Psoriasis Targeting RORγ: From Bench to Skin

BACKGROUND: Psoriasis is a chronic inflammatory skin disorder involving marked immunological changes. IL-17-targeting biologics have been successful in reducing the disease burden of psoriasis patients with moderate-to-severe disease. Unfortunately, the stratum corneum prevents penetration of large...

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Udgivet i:PLoS One
Main Authors: Smith, Susan H., Peredo, Carlos E., Takeda, Yukimasa, Bui, Thi, Neil, Jessica, Rickard, David, Millerman, Elizabeth, Therrien, Jean-Philippe, Nicodeme, Edwige, Brusq, Jean-Marie, Birault, Veronique, Viviani, Fabrice, Hofland, Hans, Jetten, Anton M., Cote-Sierra, Javier
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752338/
https://ncbi.nlm.nih.gov/pubmed/26870941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147979
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