Conformational states of syntaxin-1 govern the necessity of N-peptide binding in exocytosis of PC12 cells and Caenorhabditis elegans

Syntaxin-1 is the central SNARE protein for neuronal exocytosis. It interacts with Munc18-1 through its cytoplasmic domains, including the N-terminal peptide (N-peptide). Here we examine the role of the N-peptide binding in two conformational states (“closed” vs. “open”) of syntaxin-1 using PC12 cel...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Park, Seungmee, Bin, Na-Ryum, Michael Rajah, Maaran, Kim, Byungjin, Chou, Ting-Chieh, Kang, Soo-young Ann, Sugita, Kyoko, Parsaud, Leon, Smith, Matthew, Monnier, Philippe P., Ikura, Mitsuhiko, Zhen, Mei, Sugita, Shuzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750926/
https://ncbi.nlm.nih.gov/pubmed/26700321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-09-0638
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