A Pivotal Role for Pro-335 in Balancing the Dual Functions of Munc18-1 Domain-3a in Regulated Exocytosis

Munc18-1 plays essential dual roles in exocytosis: (i) stabilizing and trafficking the central SNARE protein, syntaxin-1 (i.e. chaperoning function), by its domain-1; and (ii) priming/stimulating exocytosis by its domain-3a. Here, we examine whether or not domain-3a also plays a significant role in...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Han, Gayoung Anna, Park, Seungmee, Bin, Na-Ryum, Jung, Chang Hun, Kim, Byungjin, Chandrasegaram, Prashanth, Matsuda, Maiko, Riadi, Indira, Han, Liping, Sugita, Shuzo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Cell Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4246113/
https://ncbi.nlm.nih.gov/pubmed/25326390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584805
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