Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells

Munc18-1 binds to syntaxin-1A via two distinct sites referred to as the “closed” conformation and N terminus binding. The latter has been shown to stimulate soluble N-ethylmaleimide-sensitive factor attachment protein receptor-mediated exocytosis, whereas the former is believed to be inhibitory or d...

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Main Authors: Han, Liping, Jiang, Tiandan, Han, Gayoung A., Malintan, Nancy T., Xie, Li, Wang, Li, Tse, Frederick W., Gaisano, Herbert Y., Collins, Brett M., Meunier, Frederic A., Sugita, Shuzo
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785739/
https://ncbi.nlm.nih.gov/pubmed/19812250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0712
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