Truncating erythropoietin receptor rearrangements in acute lymphoblastic leukemia

Chromosomal rearrangements are a hallmark of acute lymphoblastic leukemia (ALL) and are important ALL initiating events. We describe four different rearrangements of the erythropoietin receptor gene EPOR in Philadelphia chromosome-like (Ph-like) ALL. All of these rearrangements result in truncation...

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Udgivet i:Cancer Cell
Main Authors: Iacobucci, Ilaria, Li, Yongjin, Roberts, Kathryn G., Dobson, Stephanie M., Kim, Jaeseung C., Payne-Turner, Debbie, Harvey, Richard C., Valentine, Marcus, McCastlain, Kelly, Easton, John, Yergeau, Donald, Janke, Laura J., Shao, Ying, Chen, I-Ming L., Rusch, Michael, Zandi, Sasan, Kornblau, Steven M., Konopleva, Marina, Jabbour, Elias, Paietta, Elisabeth M., Rowe, Jacob M., Pui, Ching-Hon, Gastier-Foster, Julie, Gu, Zhaohui, Reshmi, Shalini, Loh, Mignon L., Racevskis, Janis, Tallman, Martin S., Wiernik, Peter H., Litzow, Mark R., Willman, Cheryl L., McPherson, John D., Downing, James R., Zhang, Jinghui, Dick, John E., Hunger, Stephen P., Mullighan, Charles G.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750652/
https://ncbi.nlm.nih.gov/pubmed/26859458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.12.013
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