Unfolded-protein response–associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

Failure of lens fiber cell denucleation (LFCD) is associated with congenital cataracts, but the pathobiology awaits elucidation. Recent work has suggested that mechanisms that direct the unidirectional process of LFCD are analogous to the cyclic processes associated with mitosis. We found that lens-...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:FASEB J
Päätekijät: Lyu, Lei, Whitcomb, Elizabeth A., Jiang, Shuhong, Chang, Min-Lee, Gu, Yumei, Duncan, Melinda K., Cvekl, Ales, Wang, Wei-Lin, Limi, Saima, Reneker, Lixing W., Shang, Fu, Du, Linfang, Taylor, Allen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Federation of American Societies for Experimental Biology 2015
Aiheet:
Research Communication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750420/
https://ncbi.nlm.nih.gov/pubmed/26590164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-278036
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