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Lens Crystallin Modifications and Cataract in Transgenic Mice Overexpressing Acylpeptide Hydrolase

The accumulation of crystallin fragments in vivo and their subsequent interaction with crystallins are responsible, in part, for protein aggregation in cataracts. Transgenic mice overexpressing acylpeptide hydrolase (APH) specifically in the lens were prepared to test the role of protease in the gen...

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Detalhes bibliográficos
Main Authors: Santhoshkumar, Puttur, Xie, Leike, Raju, Murugesan, Reneker, Lixing, Sharma, K. Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979366/
https://ncbi.nlm.nih.gov/pubmed/24554718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510677
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