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Lens Crystallin Modifications and Cataract in Transgenic Mice Overexpressing Acylpeptide Hydrolase

The accumulation of crystallin fragments in vivo and their subsequent interaction with crystallins are responsible, in part, for protein aggregation in cataracts. Transgenic mice overexpressing acylpeptide hydrolase (APH) specifically in the lens were prepared to test the role of protease in the gen...

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Main Authors: Santhoshkumar, Puttur, Xie, Leike, Raju, Murugesan, Reneker, Lixing, Sharma, K. Krishna
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979366/
https://ncbi.nlm.nih.gov/pubmed/24554718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510677
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