Unfolded-protein response–associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

Failure of lens fiber cell denucleation (LFCD) is associated with congenital cataracts, but the pathobiology awaits elucidation. Recent work has suggested that mechanisms that direct the unidirectional process of LFCD are analogous to the cyclic processes associated with mitosis. We found that lens-...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Lyu, Lei, Whitcomb, Elizabeth A., Jiang, Shuhong, Chang, Min-Lee, Gu, Yumei, Duncan, Melinda K., Cvekl, Ales, Wang, Wei-Lin, Limi, Saima, Reneker, Lixing W., Shang, Fu, Du, Linfang, Taylor, Allen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2015
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750420/
https://ncbi.nlm.nih.gov/pubmed/26590164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-278036
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