Metabolic disruption identified in the Huntington’s disease transgenic sheep model

Huntington’s disease (HD) is a dominantly inherited, progressive neurodegenerative disorder caused by a CAG repeat expansion within exon 1 of HTT, encoding huntingtin. There are no therapies that can delay the progression of this devastating disease. One feature of HD that may play a critical role i...

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Pubblicato in:Sci Rep
Autori principali: Handley, Renee. R., Reid, Suzanne J., Patassini, Stefano, Rudiger, Skye R., Obolonkin, Vladimir, McLaughlan, Clive. J., Jacobsen, Jessie C., Gusella, James F., MacDonald, Marcy E., Waldvogel, Henry J., Bawden, C. Simon, Faull, Richard L. M., Snell, Russell G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749952/
https://ncbi.nlm.nih.gov/pubmed/26864449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20681
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