Brain urea increase is an early Huntington’s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases

The neurodegenerative disorder Huntington’s disease (HD) is typically characterized by extensive loss of striatal neurons and the midlife onset of debilitating and progressive chorea, dementia, and psychological disturbance. HD is caused by a CAG repeat expansion in the Huntingtin (HTT) gene, transl...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Handley, Renee R., Reid, Suzanne J., Brauning, Rudiger, Maclean, Paul, Mears, Emily R., Fourie, Imche, Patassini, Stefano, Cooper, Garth J. S., Rudiger, Skye R., McLaughlan, Clive J., Verma, Paul J., Gusella, James F., MacDonald, Marcy E., Waldvogel, Henry J., Bawden, C. Simon, Faull, Richard L. M., Snell, Russell G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748180/
https://ncbi.nlm.nih.gov/pubmed/29229845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711243115
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