Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging

Variant late-infantile Batten disease is a neuronal ceroid lipofuscinosis caused by mutations in CLN6. It is a recessive genetic lysosomal storage disease characterised by progressive neurodegeneration. It starts insidiously and leads to blindness, epilepsy and dementia in affected children. Sheep t...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sawiak, Stephen J., Perumal, Sunthara Rajan, Rudiger, Skye R., Matthews, Loren, Mitchell, Nadia L., McLaughlan, Clive J., Bawden, C. Simon, Palmer, David N., Kuchel, Timothy, Morton, A. Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498759/
https://ncbi.nlm.nih.gov/pubmed/26161747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132331
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