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The Reverse Transcriptase Encoded by LINE-1 Retrotransposons in the Genesis, Progression, and Therapy of Cancer

In higher eukaryotic genomes, Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons represent a large family of repeated genomic elements. They transpose using a reverse transcriptase (RT), which they encode as part of the ORF2p product. RT inhibition in cancer cells, either via RNA interfer...

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Publicat a:Front Chem
Autors principals: Sciamanna, Ilaria, De Luca, Chiara, Spadafora, Corrado
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749692/
https://ncbi.nlm.nih.gov/pubmed/26904537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2016.00006
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