A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines

LINE-1 elements make up the most abundant retrotransposon family in the human genome. Full-length LINE-1 elements encode a reverse transcriptase (RT) activity required for their own retrotranpsosition as well as that of non-autonomous Alu elements. LINE-1 are poorly expressed in normal cells and abu...

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Main Authors: Sciamanna, Ilaria, Gualtieri, Alberto, Cossetti, Cristina, Osimo, Emanuele Felice, Ferracin, Manuela, Macchia, Gianfranco, Aricò, Eleonora, Prosseda, Gianni, Vitullo, Patrizia, Misteli, Tom, Spadafora, Corrado
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2013
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926826/
https://ncbi.nlm.nih.gov/pubmed/24345856
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