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Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression

LINE-1 retrotransposons encode the reverse transcriptase (RT) enzyme, required for their own mobility, the expression of which is inhibited in differentiated tissues while being active in tumors. Experimental evidence indicate that the inhibition of LINE-1-derived RT restores differentiation in canc...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Sciamanna, Ilaria, Gualtieri, Alberto, Piazza, Pier Vincenzo, Spadafora, Corrado
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226666/
https://ncbi.nlm.nih.gov/pubmed/25478632
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