Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells

Long Interspersed Elements (L1 elements) are biologically active retrotransposons that are capable of autonomous replication using their own reverse transcriptase (RT) enzyme. Expression of the normally repressed RT has been implicated in cancer cell growth. However, at present, little is known abou...

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Bibliographic Details
Main Authors: Patnala, Radhika, Lee, Sung-Hun, Dahlstrom, Jane E., Ohms, Stephen, Chen, Long, Dheen, S. Thameem, Rangasamy, Danny
Format: Artigo
Language:Inglês
Published: Springer US 2013
Subjects:
Preclinical Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889873/
https://ncbi.nlm.nih.gov/pubmed/24337508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-013-2812-7
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