Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis

Adrenergic stimulation adversely affects tumor growth and metastasis, but the underlying mechanisms are not well understood. Here, we uncovered a novel mechanism by which catecholamines induce inflammation by increasing prostaglandin E2 (PGE2) levels in ovarian cancer cells. Metabolic changes in tum...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Nagaraja, Archana S., Dorniak, Piotr L., Sadaoui, Nouara C., Kang, Yu, Lin, Tan, Armaiz-Pena, Guillermo, Wu, Sherry Y., Rupaimoole, Rajesha, Allen, Julie K., Gharpure, Kshipra M., Pradeep, Sunila, Zand, Behrouz, Previs, Rebecca A., Hansen, Jean M., Ivan, Cristina, Rodriguez-Aguayo, Cristian, Yang, Peiying, Lopez-Berestein, Gabriel, Lutgendorf, Susan K., Cole, Steve W., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749473/
https://ncbi.nlm.nih.gov/pubmed/26257064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.302
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