Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

BACKGROUND: Retinal inflammation is a devastating pathological process in ocular diseases. Functional impairment of retinal pigment epithelium (RPE) is associated with inflammatory retinal diseases. Enhancing the protective axis namely ACE2/Ang-(1-7)/Mas by activation of ACE2 presents anti-inflammat...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Tao, Lifei, Qiu, Yiguo, Fu, Xinyu, Lin, Ru, Lei, Chunyan, Wang, Jiaming, Lei, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748536/
https://ncbi.nlm.nih.gov/pubmed/26862037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0489-7
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