AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-κB and STAT3 Pathways

Renin angiotensin system (RAS) is a key hormonal system which regulates the cardiovascular function and is implicated in several autoimmune diseases. With the discovery of the angiotensin-converting enzyme 2 (ACE2), a protective axis of RAS namely ACE2/Ang-(1–7)/Mas that counteracts the deleterious...

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Vydáno v:Sci Rep
Hlavní autoři: Qiu, Yiguo, Tao, Lifei, Zheng, Shijie, Lin, Ru, Fu, Xinyu, Chen, Zihe, Lei, Chunyan, Wang, Jiaming, Li, Hongwei, Li, Qiuhong, Lei, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4997264/
https://ncbi.nlm.nih.gov/pubmed/27558087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31912
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