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Unveiling Inherent Degeneracies in Determining Population-weighted Ensembles of Inter-domain Orientational Distributions Using NMR Residual Dipolar Couplings: Application to RNA Helix Junction Helix Motifs

A growing number of studies employ time-averaged experimental data to determine dynamic ensembles of biomolecules. While it is well known that different ensembles can satisfy experimental data to within error, the extent and nature of these degeneracies, and their impact on the accuracy of the ensem...

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Bibliografiske detaljer
Udgivet i:J Phys Chem B
Main Authors: Yang, Shan, Al-Hashimi, Hashim M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748182/
https://ncbi.nlm.nih.gov/pubmed/26131693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b03859
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