KRAS insertion mutations are oncogenic and exhibit distinct functional properties

Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs). Here we discover a partial duplication of the switch 2 domain of K-Ras encoding a tandem repeat of amino acids G60_A66dup in a ch...

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Publicado no:Nat Commun
Main Authors: White, Yasmine, Bagchi, Aditi, Van Ziffle, Jessica, Inguva, Anagha, Bollag, Gideon, Zhang, Chao, Carias, Heidi, Dickens, David, Loh, Mignon, Shannon, Kevin, Firestone, Ari J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748120/
https://ncbi.nlm.nih.gov/pubmed/26854029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10647
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