Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Zimmer, Jutta, Tacconi, Eliana M.C., Folio, Cecilia, Badie, Sophie, Porru, Manuela, Klare, Kerstin, Tumiati, Manuela, Markkanen, Enni, Halder, Swagata, Ryan, Anderson, Jackson, Stephen P., Ramadan, Kristijan, Kuznetsov, Sergey G., Biroccio, Annamaria, Sale, Julian E., Tarsounas, Madalena
Format: Artigo
Langue:Inglês
Publié: Cell Press 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747901/
https://ncbi.nlm.nih.gov/pubmed/26748828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.004
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