Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Cell
Hlavní autoři: Zimmer, Jutta, Tacconi, Eliana M.C., Folio, Cecilia, Badie, Sophie, Porru, Manuela, Klare, Kerstin, Tumiati, Manuela, Markkanen, Enni, Halder, Swagata, Ryan, Anderson, Jackson, Stephen P., Ramadan, Kristijan, Kuznetsov, Sergey G., Biroccio, Annamaria, Sale, Julian E., Tarsounas, Madalena
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2016
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747901/
https://ncbi.nlm.nih.gov/pubmed/26748828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.004
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky