Selectivity of C3-opsonin targeted complement inhibitors: a distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators. Blockage of the lytic pathway by eculizumab is the only available therapy for PNH patients and shows remarkable benefits, but regularly yields PNH ery...

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Publicado en:Immunobiology
Autores principales: Schmidt, Christoph Q., Harder, Markus J., Nichols, Eva-Maria, Hebecker, Mario, Anliker, Markus, Höchsmann, Britta, Simmet, Thomas, Csincsi, Ádám I., Uzonyi, Barbara, Pappworth, Isabel Y., Ricklin, Daniel, Lambris, John D., Schrezenmeier, Hubert, Józsi, Mihály, Marchbank, Kevin J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747809/
https://ncbi.nlm.nih.gov/pubmed/26792457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2015.12.009
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