Selectivity of C3-opsonin targeted complement inhibitors: a distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated cell lysis due to deficiency of GPI-anchored complement regulators. Blockage of the lytic pathway by eculizumab is the only available therapy for PNH patients and shows remarkable benefits, but regularly yields PNH ery...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Immunobiology
Main Authors: Schmidt, Christoph Q., Harder, Markus J., Nichols, Eva-Maria, Hebecker, Mario, Anliker, Markus, Höchsmann, Britta, Simmet, Thomas, Csincsi, Ádám I., Uzonyi, Barbara, Pappworth, Isabel Y., Ricklin, Daniel, Lambris, John D., Schrezenmeier, Hubert, Józsi, Mihály, Marchbank, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747809/
https://ncbi.nlm.nih.gov/pubmed/26792457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imbio.2015.12.009
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados