The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis

While cellular GTP concentration dramatically changes in response to an organism’s cellular status, whether it serves as a metabolic cue for biological signaling remains elusive due to the lack of molecular identification of GTP sensors. Here we report that PI5P4Kβ, a phosphoinositide kinase that re...

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Publicat a:Mol Cell
Autors principals: Sumita, Kazutaka, Lo, Yu-Hua, Takeuchi, Koh, Senda, Miki, Kofuji, Satoshi, Ikeda, Yoshiki, Terakawa, Jumpei, Sasaki, Mika, Yoshino, Hirofumi, Majd, Nazanin, Zheng, Yuxiang, Kahoud, Emily Rose, Yokota, Takehiro, Emerling, Brooke M., Asara, John M., Ishida, Tetsuo, Locasale, Jason W., Daikoku, Takiko, Anastasiou, Dimitrios, Senda, Toshiya, Sasaki, Atsuo T.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747657/
https://ncbi.nlm.nih.gov/pubmed/26774281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.011
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