Degradation of Activated K-Ras Orthologue via K-Ras-specific Lysine Residues Is Required for Cytokinesis

Mammalian cells encode three closely related Ras proteins, H-Ras, N-Ras, and K-Ras. Oncogenic K-Ras mutations frequently occur in human cancers, which lead to dysregulated cell proliferation and genomic instability. However, mechanistic role of the Ras isoform regulation have remained largely unknow...

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Main Authors: Sumita, Kazutaka, Yoshino, Hirofumi, Sasaki, Mika, Majd, Nazanin, Kahoud, Emily Rose, Takahashi, Hidenori, Takeuchi, Koh, Kuroda, Taruho, Lee, Susan, Charest, Pascale G., Takeda, Kosuke, Asara, John M., Firtel, Richard A., Anastasiou, Dimitrios, Sasaki, Atsuo T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924263/
https://ncbi.nlm.nih.gov/pubmed/24338482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.531178
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